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Novel Treatment Shows Promise Against Rare Cancer In Kids

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Researchers revealed Wednesday that a novel treatment based on supercharged immune cells appeared to act against tumors in youngsters with a rare type of cancer.

Six weeks following therapy, nine of the 27 youngsters in the Italian research showed no signs of cancer, while two later relapsed and died.

The immune system is already being helped by CAR-T cell therapy to fight leukemia and other blood cancers. Experts say this is the first time researchers have gotten such promising results with solid tumors. This gives people hope that this method can treat other types of cancer.

It’s too early to call it a cure for neuroblastoma, a type of nerve tissue cancer that typically begins in childhood in the adrenal glands near the kidneys in the belly.

Standard treatment might be severe depending on the cancer stage and other considerations, requiring chemotherapy, surgery, and radiation. The youngsters in the research had cancer that had returned or was difficult to treat.

When the three-year research concluded, eleven children remained alive, including several who only partially reacted to treatment and required repeat injections of the modified cells.

Standard treatment might be severe depending on the cancer stage and other considerations.

“Those kids were all destined to die without that therapy,” said Dr. Carl June of the University of Pennsylvania, a pioneer of CAR-T therapy who was not involved in the new study.

“No one has ever had patients respond like this before, so we just don’t know what it’ll look like in a decade,” June said. “With these promising results, there will undoubtedly be more trials.”

CAR-T cell therapy uses the immune system to develop “living drugs” capable of locating and destroying tumors. T cells from the patient’s blood are collected and reinforced in the lab before being reintroduced to the patient through IV, where they multiply further.

The US Food and Drug Administration has approved six CAR-T cell treatments for blood malignancies. Some of the early rise cases were cured.

However, success with solid tumors has been difficult to come by. Researchers from the Vatican’s Bambino Gesu pediatric hospital in Rome conducted the most recent study.

Dr. Robbie Majzner of Stanford University School of Medicine, who was not involved in the current study, said, “They seem to have found a unique combination” to allow the transformed cells to multiply initially, then last a long time to continue their cancer-killing function.

Dr. Franco Locatelli, a study co-author, included a safety switch to kill the cells if a patient had a severe reaction. When one patient had issues, they flicked the safety switch, demonstrating that it functioned. However, they later discovered that the patient’s issue was caused by a brain hemorrhage unrelated to the CAR-T cells.

CAR-T therapy often causes a side effect called “cytokine release syndrome,” which is an overreaction of the immune system in young people. According to the researchers, it can be serious but is modest in most cases.

They concluded CAR-T therapy was “feasible and safe in treating high-risk neuroblastoma.”

SOURCE – (AP)

Kiara Grace is a staff writer at VORNews, a reputable online publication. Her writing focuses on technology trends, particularly in the realm of consumer electronics and software. With a keen eye for detail and a knack for breaking down complex topics, Kiara delivers insightful analyses that resonate with tech enthusiasts and casual readers alike. Her articles strike a balance between in-depth coverage and accessibility, making them a go-to resource for anyone seeking to stay informed about the latest innovations shaping our digital world.

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Good News: The Worst Could Be Over For Gas Prices This Spring

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Israel and Iran have engaged in open conflict. Ukrainian drones have routinely targeted Russian oil refineries. And OPEC continues to restrict oil production.

These frightening occurrences sparked concerns about $4 gas, harming the US economy and exacerbating inflation.

However, this has not occurred, at least yet. Gas prices in the United States have stopped growing and dropped temporarily recently.

The national average was $3.66 per gallon on Monday, down from $3.68 a week ago, according to AAA.

There is growing anticipation that gas prices will peak in the spring, if not the entire year.

Patrick De Haan, head of petroleum analysis at GasBuddy, predicts that drivers will find relief at the pump in the coming weeks.

“I’m hoping the worst is behind us,” De Haan told CNN. Unless something drastic happens, there are increasing odds the national average has hit the projected spring peak.”

Tom Kloza, worldwide head of energy analysis at the Oil Price Information Service, believes gas prices will fall in the coming weeks.

“Most of the worries from the year’s first half have been resolved. “I think we’re safe until hurricane season,” Kloza remarked.

‘Could have been far worse.’

Of course, none of this implies that gas costs are cheap. They were lower in April 2021 and spring 2020, when Covid-19 kept many Americans off the roadways.

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The Worst Could Be Over For Gas Prices This Spring

Nonetheless, a springtime peak of less than $3.70 a gallon would be a win for consumers, considering the real risk of significantly higher gas costs.

“It could have been much worse,” said Andy Lipow, owner of the consultancy firm Lipow Oil Associates.

According to AAA, drivers in just seven US states pay $4 or more per gallon for gas. All those states are in the Western part of the country, followed by California, where the average is $5.40 per gallon, up from $4.88 last year.

The national average is nowhere near the record increase above $5 per gallon in June 2022.

“It seems evident that this will not be a record-setting year. “Filling your tank will feel much more normal this year,” said De Haan.

Economic and political ramifications.

Officials in Washington would most certainly breathe a sigh of relief.

Rising gasoline costs earlier this year led to lower-than-expected inflation readings, casting uncertainty on when the Federal Reserve will be able to decrease interest rates.

A rise in petrol prices is the last thing President Joe Biden wants as he works to persuade voters of his economic message before November. According to a new CNN poll, Biden’s support rating for the economy is 34%, and for inflation, it is even lower (29%).

The Biden administration backed off plans to buy crude oil for the US Strategic Petroleum Reserve, an emergency oil stockpile, earlier this month, adding to White House concerns over petrol costs.

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Some economists expect gas prices to rise further.

Lipow believes the national average will reach $3.75 per gallon this year.

Still, that would be lower than last year’s top of $3.88 per gallon in September.

“I’m not expecting a spike in gasoline prices,” Lipow added.

There are several reasons why gas prices are now holding steady.

First, oil prices have stopped rising. On April 12, US crude oil nearly reached $88 per barrel as investors braced for Iran’s reprisal against Israel over a suspected attack on an Iranian diplomatic complex in Syria.

However, oil prices fell when Israel and its allies effectively averted the reprisal. For now, fears of a larger confrontation in the Middle East have subsided, albeit this might alter quickly. US crude fell below $83 a barrel on Monday.

There are other seasonal aspects to consider.

The transition to more expensive summer-grade gasoline at US refineries is now complete. Similarly, the reopening of refineries that had been closed for normal maintenance has aided gasoline supplies.

Record-breaking US crude output continues to increase the oil supply. All of that US oil, headed by the Permian Basin in West Texas and New Mexico, is countering OPEC+’s production cuts, which Saudi Arabia and Russia lead.

Meanwhile, gasoline demand has remained relatively low despite other indications that American consumers are spending rapidly.

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The Worst Could Be Over For Gas Prices This Spring

The hurricane season looms.

Gas prices are at risk of reaching a double peak. That’s what happened last year, when gas prices peaked in April, fell, and then returned late in the summer as excessive heat hampered US refineries.

“Weather can wreak havoc,” said Kloza, an OPIS analyst.

A major hurricane that destroys oil facilities along the US Gulf Coast is the greater risk.

Forecasters warn that the hurricane season (which normally begins on June 1) will be extremely active. Colorado State University predicts more hurricanes and named storms than ever before.

“Hurricane season is the next major hurdle,” Kloza stated.

SOURCE – (CNN)

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Gangs In Haiti Launch Fresh Attacks, Days After A New Prime Minister Is Announced

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Port-au-Prince, Haiti – Gangs in Haiti besieged multiple districts in Port-au-Prince, burning homes and exchanging Gunfire with police for hours as hundreds escaped the mayhem early Thursday, in one of the most serious attacks since Haiti’s new prime minister was appointed.

The attacks began late Wednesday in communities such as Solino and Delmas 18, 20, and 24, southwest of the main international airport, which has been shuttered for over two months due to ongoing gang violence.

“The gangs started burning everything in sight,” said a man named Néne, who refused to disclose his last name due to fear. “I was hiding in a corner all night.”

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Gangs In Haiti Launch Fresh Attacks, Days After A New Prime Minister Is Announced

He walked with a companion, carrying a dusty red bag crammed with clothes—the only thing they could preserve. The garments belonged to Néne’s children, whom he had whisked out of Delmas 18 in the morning during a lull in the battle.

The neighborhoods formerly bustling with cars and pedestrians were like ghost towns long after morning, with only the occasional bleating from a lone goat breaking the calm.

An armored police truck patrolled the streets, passing burnt vehicles and cinderblock walls with the scrawled “Viv Babecue,” a reference to one of Haiti’s most powerful gang bosses.

People who escaped the onslaught in Delmas 18 and other adjacent communities held fans, stoves, mattresses, and plastic bags packed with clothes as they left on foot, on motorcycles, or in colorful mini buses known as tap-taps. Others were walking empty-handed after losing everything.

“There were gunshots left and right,” claimed Paul Pierre, 47, who was walking with his girlfriend looking for safety after their house burned down. They couldn’t salvage any of their possessions.

He stated that the nocturnal battle ripped children from their parents and husbands from their wives as people fled in terror, adding, “Everyone is just trying to save themselves.”

Martina, a woman who refused to provide her last name out of fear, claimed she was left homeless after armed assailants burnt her home. She fled with her 4-year-old, who she claims attempted to flee when the shooting started late Wednesday.

“I told him, ‘Don’t be afraid. “This is life in Haiti,” she remarked as she held a hefty load of goods on her head, including butter, which she wanted to sell to generate money and find a new home.

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Gangs In Haiti Launch Fresh Attacks, Days After A New Prime Minister Is Announced

When asked to describe what transpired overnight, she answered, “Gunfire, Gunfire, everywhere! Nobody slept. “Everybody was running.”

Jimmy Chérizier, the head of the formidable gang federation G9 Family and Allies and a former elite police officer known as Barbecue, was in charge of the area where the incident occurred.

He and other gang bosses have been blamed for the coordinated attacks that began on February 29 in the capital, Port-au-Prince. Gunmen have torched police stations, opened fire on the main international airport, and stormed Haiti’s two largest prisons, freeing over 4,000 inmates.

The attacks eventually forced Prime Minister Ariel Henry to resign, prompting the formation of a transitional presidential council. The council’s majority unexpectedly announced a new prime minister on Tuesday: Fritz Bélizaire, a former sports minister. The action threatens to split the nine-member council, which was sworn in last week.

As new authorities take over the country amid fighting, Haitians demand that they prioritize their protection, as gangs remain more strong and well-armed than the Haitian National Police.

More than 2,500 people were murdered or injured between January and March of this year, a more than 50% rise over the same period last year, according to the United Nations.

Meanwhile, over 90,000 individuals have fled Port-au-Prince in just one month, as gangs controlling an estimated 80% of the capital increasingly target formerly tranquil districts.

Ernest Aubrey told how he relocated to Delmas 18 years ago. He’s leaving home for the first time.

AP – VOR News Image

Gangs In Haiti Launch Fresh Attacks, Days After A New Prime Minister Is Announced

“It is too much. “We can’t resist any longer,” he said of the gangs. “They are taking everything we own.”

As he went with his heavy backpack, he noticed an acquaintance leaving in a car and dashed toward them to see if he could catch a ride.

Vanessa Vieux was one of the few who stayed at Delmas 18. Early Wednesday after the incident, she relocated her elderly mother to the countryside. She thought it was best not to give her home over to gangs. Furthermore, she has faith in Haiti’s National Police.

“I live next to a police officer,” she explained. “That’s why I’m not scared.”

SOURCE – (AP)

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Russia Proposes UN Resolution On Banning Weapons In Space, After Vetoing Similar UN-Japan Draft

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United Nations  — A week after vetoing a U.S.-Japan resolution to halt an arms race in space, Russia circulated a UN resolution urging all countries to take immediate steps to prevent weapons from being placed in outer space “forever.”

The Russian draft resolution, goes beyond the U.S.-Japan plan by calling not only for steps to prevent weapons from being deployed in outer space but also for preventing “the threat or use of force in outer space,” “for all time.”

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Russia Proposes UN Resolution On Banning Weapons In Space, After Vetoing Similar UN-Japan Draft

It states that this should include deploying weapons “from space against Earth, and from Earth against objects in outer space.”

When Russia’s UN Ambassador Vassily Nebenzia rejected the United States-Japan draft, he warned the Security Council that it did not go far enough in outlawing all sorts of weapons in space.

The vetoed resolution only addressed weapons of mass destruction, including nuclear weapons, and made no mention of other weapons in space.

It would have urged all countries to refrain from developing or deploying nuclear weapons or other weapons of mass destruction in space, as prohibited by a 1967 international convention adopted by the United States and Russia, and to recognize the importance of verifying compliance.

Before the US-Japan resolution was voted on April 24, Russia and China presented an amendment calling on all countries, particularly those with space capabilities, “to prevent for all time the placement of weapons in outer space, and the threat of use of force in outer spaces.”

Seven countries voted in favor, seven against, and one abstention, and the amendment failed to receive the requisite nine “yes” votes in the 15-member Security Council.

Following the decision, US Ambassador Linda Thomas-Greenfield informed the council that Russian President Vladimir Putin has stated that Moscow has no intention of placing nuclear weapons in space.

“Today’s veto raises the question: why? Why, if you are obeying the rules, would you oppose a resolution that reinforces them? “What could you possibly be hiding?” she inquired. “It’s confusing. And it is a disgrace.”

AP – VOR News Image

Russia Proposes UN Resolution On Banning Weapons In Space, After Vetoing Similar UN-Japan Draft

Putin was responding to the White House’s revelation in February that Russia had acquired a “troubling” anti-satellite weapon capability, but such a weapon is not yet operational.

Vassily Nebenzia, Russia’s UN Ambassador, said after casting the veto that the US-Japan resolution cherry-picked weapons of mass devastation.

He emphasized that the US and its partners had already revealed plans to deploy weapons in outer space, which explains their activities.

Nebenzia also claimed that the United States has been opposing a Russian-Chinese proposal for a convention prohibiting the deployment of weapons in outer space since 2008.

Thomas-Greenfield accused Russia of undermining global treaties to prevent the spread of nuclear weapons, recklessly invoking “dangerous nuclear rhetoric,” abandoning several arms control obligations, and refusing to engage “in substantive discussions around arms control or risk reduction.”

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Russia Proposes UN Resolution On Banning Weapons In Space, After Vetoing Similar UN-Japan Draft

Much of the Russian draft resolution is identical to the US-Japan text, including the wording aimed at averting an arms race in space.

It urges all countries, particularly those with significant space capabilities, “to actively contribute to the goal of the peaceful use of outer space and the prevention of an arms race in outer space.”

According to Thomas-Greenfield, the world is only beginning to realize “the catastrophic ramifications of a nuclear explosion in space.”

SOURCE – (AP)

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