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Scientists Create Mice With Cells From 2 Males For 1st Time

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Scientists have produced baby mice from two guys for the first time.

Although specialists caution that only a few mice embryos matured into live mouse pups, and no one knows whether it will work for humans, this raises the remote potential of employing the same approach on people.

But even so, “It’s a pretty creative method,” said Diana Laird, a stem cell and reproductive person at the University of California, who was not involved in the study. It’s a crucial phase in both reproductive biology and stem cell research.

Researchers revealed their work in a paper published in the journal Nature on Wednesday.

First, they created “induced pluripotent stem cells” from skin cells removed from the tails of male mice. These cells can differentiate into a variety of different cell or tissue types. They then developed functioning egg cells by converting male mouse stem cells into female cells by expanding them and administering medication. The embryos were then placed into female mice after being fertilized. 7 of the 630 embryos, or around 1%, developed into living mouse pups.

Last week, scientists at the Third International Conference on Human Genome Editing heard from research leader Katsuhiko Hayashi of Kyushu University and Osaka University in Japan that the pups appeared to develop properly and could become parents on their own in a typical way.

Laird and her colleague Jonathan Bayerl wrote a commentary that was published alongside the Nature publication in which they stated that the work “opens up new pathways in reproductive biology and mice fertility research” for both people and animals. In the future, it is feasible to procreate endangered mammals from a single male.

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Unclear why so few embryos implanted into surrogate mice survived.

They said it “could even give a pattern for enabling more people to produce biological children while avoiding the ethical and legal concerns of donor eggs,” such as male same-sex couples.

However, they issued multiple warnings. Which is the most notable? The method could be more effective. They claimed it was unclear why so few embryos implanted into surrogate mice survived; there may be technical or biological reasons for this. However, they emphasized that it is still too early to determine whether the approach would even function with human stem cells.

Before employing stem cells to create eggs, Laird added that researchers must consider the mutations and mistakes that might be made in a culture dish.

The most recent study explores novel approaches to in vitro mouse embryogenesis. This summer, researchers in Israel and California developed “synthetic” mouse embryos from stem cells that lacked a mother’s ovum or egg.  Up to 8 12 days after conception, those mice embryos had the same characteristics as typical mouse embryos, including one that resembled a beating heart. The achievement, according to scientists, could one day serve as a model for producing artificial human embryos for future research.

SOURCE – (AP)

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Sweden Close To Becoming First ‘Smoke Free’ Country In Europe For 2024

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STOCKHOLM — In Sweden’s outdoor bars and eateries, summer is in the air but not cigarette smoke.

The World Health Organisation will observe “World No Tobacco Day” on Wednesday, and Sweden, which has the lowest smoking rates in the European Union, is almost ready to declare itself “smoke free” (defined as having fewer than 5% of the population smoking every day).

While others refer to the presence of “snus,” a smokeless tobacco product prohibited elsewhere in the E.U. but marketed as an alternative to cigarettes in Sweden, many experts credit decades of anti-smoking campaigns and laws.

Regardless of the cause, the 5% goal is now within sight. According to the statistics agency Eurostat, only 6.4% of Swedes over 15 smoked every day in 2019, the lowest rate in the E.U. and significantly lower than the average of 18.5% for the 27-nation bloc.

According to statistics from Sweden’s Public Health Agency, the smoking rate has decreased since then and last year, it was 5.6%.

Carina Astorsson, a Stockholm resident, claimed that the reason was that “we like a healthy way of living.” She said she had never been interested in smoking because “I don’t like the smell; I want to take care of my body.”

Younger generations of health-conscious Swedes appear to be aware of the dangers of smoking. Nearly 20% of people smoked 20 years ago, a low rate globally. Since then, anti-smoking policies, such as those that forbid smoking in restaurants, have reduced the smoking rate throughout Europe.

From 2014 to 2019, France saw record-low smoking rates, but this progress halted during the COVID-19 epidemic, which is partly blamed for creating the stress that led to smoking. In France, about one-third of those between 18 and 75 admitted smoking in 2021, a small rise from the previous year. 25% of people smoke every day.

Sweden, which has the lowest smoking rates in the European Union, is almost ready to declare itself “smoke free”.

Sweden has taken more steps than others to outlaw smoking, and the country claims that this has positively impacted several health factors, including a comparatively low rate of lung cancer.

According to Ulrika Rehed, secretary-general of the Swedish Cancer Society, “We were early in restricting smoking in public spaces, first in school playgrounds and after-school centers, and later in restaurants, outdoor cafes, and public places like bus stations.” Taxes on cigarettes and severe regulations on marketing these items have been significant concurrent factors.

She continued, “Sweden is not there yet,” pointing out that smoking prevalence is higher among underprivileged socioeconomic categories.

In the 10.5 million-person nation, seeing individuals lighting up is getting harder and harder. Outside the entrances to hospitals and other public facilities, as well as at bus stops train platforms, and smoking is not permitted. Like most of Europe, Sweden has a smoking prohibition extending to bars and restaurants’ outdoor seating areas as of 2019.

On Tuesday night, many people ate and drank on Stockholm’s terraces as the sun sank. While cigarettes were not present, some tables did have snus cans. Some drinkers put tiny pouches of moist tobacco under their upper lips between beer sips.

Long promoting their product as a less dangerous alternative to smoking, Swedish snus manufacturers take pride in the nation’s dropping smoking rates. Health officials in Sweden hesitate to suggest smokers switch to snus, another extremely addictive nicotine substance.

Rehed declared, “I don’t see any justification for pitting two harmful products against one another.” “It is true that smoking is more dangerous than most other activities, including snus. But even with snus, there are numerous health hazards.

Snus use during pregnancy has been associated in certain studies with an increased risk of heart disease, diabetes, and preterm births.

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Sweden, which has the lowest smoking rates in the European Union, is almost ready to declare itself “smoke free”.

When Sweden joined the E.U. in 1995, they wanted an exception to the E.U.’s ban on smokeless tobacco since they are so fond of their snus, a distant relative of dipping tobacco in the United States.

“It’s part of the Swedish culture; it’s like the Swedish equivalent of Italian Parma ham or any other cultural habit,” said Patrik Hildingsson, a spokesman for Swedish Match, the leading snus producer in Sweden that tobacco giant Philip Morris recently purchased.

According to him, policymakers should push the tobacco industry to create less dangerous smoking substitutes like snus and e-cigarettes.

“I mean, there are still 1.2 billion smokers in the globe. In the E.U., almost 100 million individuals smoke every day. And I believe that the restrictions on policymaking are limited,” he remarked. You will need to offer smokers various alternate, less dangerous options.

Turkmenistan, which has a tobacco consumption rate below 5%, is ahead of Sweden in terms of phasing out smoking, according to WHO, the U.N. health office. However, it should be noted that this is mostly because smoking is virtually nonexistent among women. The rate is 7% for men.

The WHO credits a variety of tobacco control initiatives, such as education programs, restrictions on tobacco advertising, and “cessation support” for smokers who want to give up the habit, for Sweden’s dropping smoking rate. However, the agency pointed out that when you include snus and similar products, tobacco usage in Sweden is higher than 20% of the adult population, comparable to the global average.

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Sweden, which has the lowest smoking rates in the European Union, is almost ready to declare itself “smoke free”.

In an email, which stated that “changing from one harmful product to another is not a solution.” The tobacco industry is attempting to deceive consumers about how deadly these products are by promoting a purported “harm reduction approach” to smoking.

According to Tove Marina Sohlberg, a researcher at the Department of Public Health Sciences at Stockholm University, Sweden’s anti-smoking laws stigmatize smoking and smokers, driving them into designated smoking locations and out of sight in public places.

She claimed that we are telling smokers their behavior is unacceptable in society.

One of the few remaining smokers in Stockholm, Paul Monja, thought about his habit as he prepared to light up.

He described it as an addiction that he hoped to overcome at some point. “Perhaps not now, maybe tomorrow.”

SOURCE – (AP)

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2023: Ruling Clears Way For Purdue Pharma to Settle Opioid Claims, Protect Sacklers From Lawsuits

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On Tuesday, a federal judge issued a verdict that allowed Purdue Pharma, the producer of OxyContin, to settle hundreds of lawsuits over the devastating effects of opioids.

The affluent Sackler family of Stamford, Connecticut, would sell their stake in Purdue to a new business called Knoa, with the proceeds going towards combating the opioid crisis. This proposal was authorized by the 2nd U.S. Circuit Court of Appeals in New York. They would also make a long-term monetary investment of between $5.5 and $6 billion. At least $750 million will be distributed to opioid crisis victims and their families. Victims’ compensation is included in only one other large opioid lawsuit settlement.

Even though the Sackler family did not file for bankruptcy on Tuesday, they are shielded from legal action related to the opioid crisis due to the court’s judgment.

The judgment overturned a lower court decision from 2021, which held that judges in bankruptcy court had the authority to accept a deal that would extend bankruptcy protections to people who have not formally filed for bankruptcy.

The proposed settlement to resolve claims against Purdue brought by hundreds of state, local, and Native American tribal governments and other entities centers on these safeguards.

Ed Neiger, a lawyer for individual victims, said, “It’s a great day for victims, some of whom desperately need the money and have been waiting for this day for a long time.”

Members of the Sackler family have made it plain that they will only fulfill their obligations under the agreement if they are granted certain legal protections.

In a statement released on Tuesday, the Sackler family, who owns Purdue, said, “The Sackler families believe the long-awaited implementation of this resolution is critical to providing substantial resources for people and communities in need.” To paraphrase, “We are pleased with the Court’s decision to allow the agreement to move forward and look forward to it taking effect as soon as possible.”

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A federal judge issued a verdict that allowed Purdue Pharma, the producer of OxyContin, to settle hundreds of lawsuits over the devastating effects of opioids.

In its statement, Purdue hailed the decision as “a victory for Purdue’s creditors, including the states, local governments, and victims who overwhelmingly support the Plan of Reorganisation.” The business has stated that it will prioritize providing “billions of dollars in value for victim compensation, opioid crisis abatement, and overdose rescue medicines.”

After a second round of negotiations late last year, all states previously on the fence about supporting the proposal finally joined in. There was only one major holdout, the Justice Department’s U.S. Bankruptcy Trustee’s Office.

In April 2022, a lawyer from that department argued before the 2nd Circuit that it was “fundamentally inconsistent” to allow some lawsuits to be dismissed from the cases of people who did not file for bankruptcy and thereby lost most of their assets.

The Justice Department did not immediately announce its intention to appeal the Supreme Court’s verdict on Tuesday. On Tuesday, a spokeswoman said they would not comment.

A judge in the bankruptcy court will need to approve the most recent version of the deal before it can go into effect.

Even while the Sackler family is still the legal owner of Purdue, they have not been compensated in years.

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A federal judge issued a verdict that allowed Purdue Pharma, the producer of OxyContin, to settle hundreds of lawsuits over the devastating effects of opioids.

After hearing arguments in the Purdue case last year, all three federal appeals judges concluded that the Sackler family could be shielded from legal action. Even if courts permit such arrangements, bankruptcy law does not, as one judge, Richard Wesley, pointed out in a separate judgment.

Regarding the opioid industry, Purdue may be the most well-known company. However, not only has one medicine manufacturer been sued by state and local governments, but so have several distribution corporations and pharmacies. Some lawsuits have gone to trial, but many more are being settled out of court.

More than $50 billion has been offered or paid out in settlements in the past few years. Drug manufacturers Johnson & Johnson and Teva, wholesalers AmerisourceBergen, Cardinal Health, McKesson, and retail pharmacies CVS, Walgreens, and Walmart all have agreements. More than half a million deaths in the United States over the previous two decades have been connected to the opioid problem, with over 70,000 deaths annually in recent years.

Fentanyl and other illegal synthetic opioids, not prescription painkillers, have been mostly responsible for deaths in recent years.

SOURCE – (AP)

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US Study Finds 1 In 10 Get Long COVID- 19 After Omicron

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WASHINGTON, DC covid-19 — Research of over 10,000 Americans hopes to shed light on the illness by revealing that about 10% of persons suffering from protracted COVID-19 following an omicron infection, a lower estimate than earlier in the epidemic.

Preliminary data from a study funded by the National Institutes of Health emphasize a dozen symptoms that most characterize chronic COVID, the umbrella term often encompassing devastating health problems that can linger months or years following even a moderate occurrence of COVID-19.

Long COVID affects millions worldwide, causing symptoms like fatigue and brain fog. Researchers have not yet determined a cure, an effective treatment, or even a reliable method of diagnosis. The key to research getting those answers is better describing the illness.

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Long COVID affects millions worldwide, causing symptoms like fatigue and brain fog.

Dr. Leora Horwitz of NYU Langone Health and one of the study’s authors, noted, “Sometimes I hear people say, ‘Oh, everybody’s a little tired.'” “No, it’s crucial to understand that long-term COVID-19 patients are unique.”

More than 8,600 persons who had COVID-19 at various stages in the pandemic are included in the new study published Thursday in the Journal of the American Medical Association, along with 1,100 controls.

About one-third of COVID-19 patients, by some accounts, have had chronic COVID-19. This is consistent with the experience of NIH research participants who reported being ill before the omicron variant arrived in the United States in December 2021. At the same time, recruitment for the study began, and scientists speculated that those who had already been experiencing COVID symptoms for some time could be more interested in participating.

In contrast, only roughly 10% of study participants who had their first coronavirus infection after the study began and were, therefore, able to report symptoms in real time continued to have them six months later.

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While previous studies revealed a decrease in long COVID -19risk with the appearance of omicron, its descendants continue to spread today.

The main issue is how to find people who have long-term COVID and help them.

The present study identified Twelve symptoms as potentially defining long-term COVID: exhaustion, confusion, dizziness, nausea, vomiting, abdominal pain, chest pain, erectile dysfunction, loss of smell or taste, thirst, persistent cough, and odd movements.

Researchers rated the severity of the symptoms to provide a benchmark that might be used in future studies of potential long-term treatments for COVID, whether as part of the NIH study or elsewhere, to ensure that like patients are enrolled.

Horwitz emphasized that the list was not meant to be used by doctors to diagnose extended COVID but as a tool for future study. The long-term effects of the coronavirus can affect patients with a single symptom, multiple symptoms, or even no symptoms at all.

Horwitz said, “we don’t even know what that means,” despite the widespread interest in researching extended COVID.

SOURCE – (AP)

 

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